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Controversies in the Use of Procalcitonin to Diagnose Sepsis
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Educational Podcast Series
Episode 13 - Procalcitonin Versus Lactate: The Pros and Cons of These Two Indicators of Sepsis LISTEN NOW

Managing Patients with Sepsis

Second to heart attacks, sepsis is the leading cause of death in the intensive care unit. As many as 750,000 patients progress into severe sepsis each year in U.S. hospitals, and approximately 200,000 of these patients do not survive.*

In treating sepsis, the first hour can be critical and the first 24 can be decisive.

Sepsis can be extremely difficult to diagnose because its primary symptoms mimic the symptoms of several other critical care conditions, including myocardial infarction, pneumonia, pulmonary embolism and other high-morbidity conditions. And because of the aggressive nature of sepsis, diagnosing and initiating treatment of this infection needs to happen as soon as possible. Access to specific information may increase the accuracy of sepsis diagnostics during the critical early stages.

The need for more effective strategies to help manage sepsis is urgent.

This site was developed to increase awareness and share knowledge related to the use of Procalcitonin and other testing techniques and systems that can be used in diagnosing, treating and managing sepsis.

*Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-1310.

What is the primary tool you use to diagnose sepsis?

Procalcitonin:

This biomarker is recognized as a useful tool in the diagnostic process. It has been shown that PCT can contribute to optimization of antibiotic therapy and monitor treatment duration. One major advantage of PCT compared to other parameters is its early and highly specific increase in response to severe systemic bacterial infections and sepsis.
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Early Recognition and Risk Assessment of the Septic Patient: Part 1 & 2.


Presented by Dr. Carl Flatley, Dr. Mark Oltermann, Dr. Devandra Amin and Sr. Stephen Haire.
Over the past decade, numerous studies have investigated the use of procalcitonin (PCT) as a diagnostic test for sepsis.

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